Lifetime alcohol consumption and upper aero-digestive tract cancer risk in the Melbourne Collaborative Cohort Study

H Jayasekara; RJ MacInnis; AM Hodge; JL Hopper; GG Giles; R Room; DR English

Journal article

Lifetime alcohol consumption and upper aero-digestive tract cancer risk in the Melbourne Collaborative Cohort Study

H Jayasekara, RJ MacInnis, AM Hodge, JL Hopper, GG Giles, R Room, DR English

Cancer Causes and Control | Published : 2015

DOI: 10.1007/s10552-014-0495-y

Abstract

Purpose: Cohort studies have rarely examined the association between upper aero-digestive tract (UADT) cancer risk and lifetime alcohol intake. We examined the associations between incident squamous cell carcinoma of the UADT (oral cavity, pharynx, larynx, and esophagus) and alcohol intake for different periods in life using data from the Melbourne Collaborative Cohort Study. Methods: Usual alcohol intake for 10-year periods from age 20 was calculated using recalled frequency and quantity of beverage-specific consumption. Cox regression with age as the time axis was performed to estimate hazard ratios (HR) and 95 % confidence intervals (CI) for the associations of UADT cancer with alcohol in..

View full abstract

University of Melbourne Researchers

Harindra Jayasekara Author

Robert MacInnis Author

Allison Hodge Author

Graham Giles Author

Related Projects (4)

Epidemiology of chronic disease, health interventions and DNA studies

PLATYPUS

This proposal builds on the applicants’ experience with existing large prospective studies and on studies of families of patients with bowel..

LIFETIME ALCOHOL CONSUMPTION AND RISK OF ALL-CAUSE AND CAUSE-SPECIFIC MORTALITY: THE MELBOURNE COLLABORATIVE COHORT STUDY

Australia has a high alcohol consumption rate with many people drinking above recommended national guidelines. Alcohol is attributed with a ..

THE HEALTH 2020 COHORT STUDY (HEALTH 2020)

Our aim is to develop appropriate infrastructures necessary to facilitate access by researchers to the accumulated data, including questionn..

Grants

Awarded by Department of Health, State Government of Victoria

Funding Acknowledgements

We thank the original investigators and the diligent team, who recruited the participants and who continue working on follow-up, for their contribution. We also express our gratitude to the many thousands of Melbourne residents who continue to participate in the study. This study was funded by grants from the National Health and Medical Research Council (209057, 251533, 396414). Cohort recruitment was funded by VicHealth and The Cancer Council Victoria. Further infrastructure support was provided by The Cancer Council Victoria. HJ is the recipient of a postgraduate scholarship from the National Health and Medical Research Council (1017346). JLH is a National Health and Medical Research Council Senior Principal Research Fellow. RR's position is funded by the Victorian Department of Health and the Foundation for Alcohol Research and Education.